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INDONESIA
Indonesian Journal of Tropical and Infectious Disease
Published by Universitas Airlangga
ISSN : 20851103     EISSN : 23560991     DOI : -
Core Subject : Health, Science,
Earth & Planetary Sciences Health Professions Medicine & Pharmacology Public Health
This journal is a peer-reviewed journal established to promote the recognition of emerging and reemerging diseases specifically in Indonesia, South East Asia, other tropical countries and around the world, and to improve the understanding of factors involved in disease emergence, prevention, and elimination. The journal is intended for scientists, clinicians, and professionals in infectious diseases and related sciences. We welcome contributions from infectious disease specialists in academia, industry, clinical practice, public health, and pharmacy, as well as from specialists in economics, social sciences and other disciplines.
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Articles 8 Documents
 1 
Search results for , issue "Vol. 9 No. 1 (2021)" : 8 Documents clear
Genital Tract Infection during Pregnancy and its Association with Preterm Delivery Tri Nugraha Susilawati; Yohanes Aditya Adhi Satria
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i3.11460

Abstract

Genital tract infection (GTI) remains a significant health concern. It is estimated that in 2016, there were 370 million people who suffer from chlamydia, gonorrhea, and trichomoniasis; and 708 million others suffer from genital herpes and condyloma acuminatum. It has been reported that in pregnant women, GTI is associated with preterm delivery. The mechanisms of GTI-associated preterm delivery need to be further understood to prevent neonatal mortality and morbidity that could be the risk factor for neonates’ growth and development disorders. This article aims to describe various types of GTI and the associated pathogenesis causing preterm birth. A literature search was conducted to retrieve recent articles published in English from online databases including Pubmed, ScienceDirect, and Google Scholar. This literature study found that GTI evokes inflammatory responses that trigger several mechanisms leading to preterm delivery. The inflammatory responses in GTI include the production of proinflammatory cytokines and robust activation of neutrophils. The key mechanisms that stimulate preterm delivery in GTI include the events of early uterine contraction, preterm premature rupture of membranes, and induction of cervical ripening; which are under normal circumstances in a full-term pregnancy, those mechanisms are regulated by progesterone and prostaglandin levels along with suppression of the inflammatory responses. In conclusion, this paper has described the underlying mechanisms of preterm delivery in pregnant women with ISG. However, such mechanisms remain unclear in candida and gonococcal infection; thus, prompting the need for further studies. 
Intestinal Parasitic Infection, The Use of Latrine, and Clean Water Source In Elementary School Children At Coastal And Non-Coastal Areas, Sumenep District, Indonesia Raden Bagus Yanuar Renaldy; M. Ahda Naufal Aflahudin; Zukhaila Salma; Sumaryono Sumaryono; Muhammad Yasin Fitriah; Sri Wijayanti Sulistyawati; Dominicus Husada; Sukmawati Basuki
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.22578

Abstract

Inadequate latrine and water source cause transmission of intestinal parasitic infection, particularly in children. There is a lack information about it and it is needed to be investigated. This study aimed to compare the prevalence of intestinal parasitic infection, the use of latrine and clean water source in elementary school children at coastal and non-coastal areas in Sumenep District, Indonesia. An analytic observational study with cross sectional design was conducted in Dasuk Timur Elementary School located at coastal area, and Kolor II Elementary School at non-coastal area, Sumenep district, in January 2020. Intestinal parasites in students’ stools were identified by microscopic examination using wet direct smear stained with lugol. The use of latrine and water sources were analyzed with questionnaire. A total of 68 children stools were collected from both elementary schools. Worm infections were not found. Thirty-one children (31/44, 70.5%) from Dasuk Timur Elementary School and eight children (8/24, 33.3%) from Kolor II Elementary School were infected with intestinal protozoan and significant difference (P=0.003, Chi-square test). Blastocystis hominis was highly found in stools of Dasuk Timur Elementary School’s students (31/44, 70.5%) and significantly different from Kolor II Elementary School’s students (P<0.0001, Chi-square test). Three children (3/44, 6.8%) from Dasuk Timur Elementary School were still practicing open defecation. Dasuk Timur Elementary School’s students suffered from intestinal parasitic infection were mostly using non-piped water source (20/31, 64.5%) and were significantly different between two elementary schools (P=0.015, Fisher’s exact test). Prevalence of intestinal parasitic infections in children was found higher in coastal than non-coastal area due to the commonly use of unclean water sources and inadequate latrine. 
Correlation Between Climate Factors with Dengue Hemorrhagic Fever Cases in Surabaya 2007- 2017 Nadhilah Putri Ghaisani; Sulistiawati Sulistiawati; Maria Lucia Inge Lusida
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.16075

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease caused by dengue virus. DHF is mediated by the mosquito vector, the Aedes mosquito. The proliferation of dengue vector is influenced by many factors, one of which is climate factors. DHF is one of the main public health problems in Indonesia. Cases of dengue were first discovered in 1968 in the city of Jakarta and Surabaya. Currently Surabaya is one of the dengue endemic areas in Indonesia. . The case of DHF in the city of Surabaya can be said to be still quite high compared with another city in Indonesia, although there is a decrease in the number from year to year. When examined, many factors influence the high number of dengue cases in Surabaya, one of which is climate factor. Climate factors play a role in the proliferation of DHF vectors. Therefore, this study aims to examine for 10 years, namely in 2007 - 2017 whether there is a correlation between climate factors with dengue cases in the city of Surabaya., which in this study the climate factors used are rainfall, average temperature, and average air humidity. This research uses an analytical method namely Spearman on the SPSS software version 20. The results obtained that the case of DHF in the city of Surabaya has no relationship with climatic factors such as rainfall and average temperature with a significance value of the relationship p> 0.05. While the climate factor that has a relationship with DHF cases in Surabaya City is air humidity with a significance value of p <0.05 and has a positive relationship with the value of r = + 0.190. It can be concluded that not all climate factors have a relationship with the DHF case in Surabaya in 2007 - 2017, which has a relationship with the DHF case is air humidity. 
Plasmodium falciparum Breath Metabolomics (Breathomics) Analysis as a Non-Invasive Practical Method to Diagnose Malaria in Pediatric Ignatius Ivan; Maureen Miracle Stella; Kevin Tandarto; Fanny Budiman; Freggy Spicano Joprang
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.24069

Abstract

Children under 5 years of age are particularly vulnerable to malaria. Malaria has caused 445,000 deaths worldwide. Currently, rapid diagnostic tests (RDTs) are the fastest method to diagnose malaria. However, there are limitations that exist such as low sensitivity in detecting infections with low parasitemia. Practical, non-invasive and high ability tests to detect parasite are needed to find specific biomarkers for P. falciparum infection to determine the potential of P. falciparum 4 thioether in breathomics analysis by GC-MS as a practical non-invasive method in diagnosing malaria in pediatrics. Literature reviews from Google Scholar and ProQuest were published no later than the last 5 years. The concept of breathomics is that the breath’s volatile organic compounds (VOCs) profile is altered when the health condition changes. Breath samples from individuals infected with P. falciparum malaria were taken by exhalation. Through GC-MS analysis, it was found that 4 thioether compounds (allyl methyl sulfide (AMS), 1-methylthio-propane, (Z) -1-methylthio-1-propene and (E) -1-methylthio-1-propene) underwent a significant change in concentration during the infection. Based on experiments conducted on mice and humans, the breathomics method is known to be able to detect parasitemia levels up to <100 parasites/µL, has a sensitivity level of about 71% to 91% and a specificity of about 75% to 94%. The discovery of 4 thioether compounds by GC-MS is a strong indication of malaria, because it has the potential for high sensitivity and specificity, and the detection power exceeds the ability of RDTs.
Influence of TLR-8 Gene Polymorphisms (rs3764880 and rs3788935) Associated to Pulmonary Tuberculosis in Kupang, Indonesia Afandi Charles; Simeon Penggoam; Ani Melani Maskoen; Edhyana Sahiratmadja
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.22056

Abstract

Toll-like receptor 8 (TLR-8) is known as part of intracellular signaling transduction for bacterial phagocytosis. Mycobacterium tuberculosis (Mtb) is intracellular pathogenic bacteria that is recognized by this receptor, and genetic variation of TLR-8 might alter susceptibility of the host towards pulmonary tuberculosis (PTB). This study aimed to determine whether TLR-8 gene polymorphisms were associated to PTB in Kupang, Indonesia. This case-control study compared demographic and clinical data between 115 PTB patients and 115 controls, then two TLR-8 single nucleotide polymorphisms (rs3764880 and rs3788935) were explored using the GoldenGate® Genotyping for VeraCode® / BeadXpress Illumina®. There is no significant difference between sex distribution of patient vs control groups. The polymorphisms (rs3764880 and rs3788935) are in Hardy-Weinberg Equilibrium in this population (p > 0.05). The distribution of major vs minor genotypes and alleles of TLR-8 polymorphisms in PTB patients were as followed: rs3764880 (GG vs GA vs AA, 50.0% vs 21.4% vs 28.6% ; G vs A, 60.9% vs 39.1% ) and rs3788935 (GG vs GA vs AA, 53.0% vs 21.7% vs 25.3%; G vs A, 62.9% vs 37.1%). Neither genotypes nor alleles were associated with PTB in this population (P > 0.05). Besides, when the analyses were stratified by gender, none of the alleles of polymorphism in both genders were associated with PTB cases. None of the TLR-8 polymorphisms have associated the risk of developing PTB in Kupang, East Nusa Tenggara population (as opposed to other studies in different ethnic groups). These might reflect the diversity of genetic polymorphisms in eastern Indonesia populations, suggesting different genetic backgrounds with western part of Indonesia. 
Validity of Method for MTBC and NTM Detection in FNAB Specimens from Tuberculous Lymphadenitis Using Microscopy, XPERT MTB / RIF and Culture Method Herisa Nataliana Junus; Ni Made Mertaniasih; Soedarsono Soedarsono
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.16043

Abstract

Mycobacterium tuberculosis and Nontuberculous Mycobacteria usually cause infection in tuberculous lymphadenitis. To improve accuracy of the detection MTB and NTM bacteria it is necessary to select valid methods. This study aims to compare validity of diagnostic methods from FNAB specimens for determining tuberculous lymphadenitis patients. a descriptive observational laboratory study involved 35 samples were obtained from tuberculous lymphadenitis patients in Dr. Soetomo Hospital Surabaya East Java. All specimens examined Ziehl-Neelsen staining microscopy, Xpert MTB/RIF , culture method Middlebrook7H10 solid media and  MGIT as Gold standard. Identification of MTB dan NTM with SD Bioline TB Ag MPT64 and niacin paper strip BD . Used diagnostic test 2x2 to analyze sensitivity, specificity, negative predictive value and positive predictive value. Ziehl-Neelsen staining microscopy Sensitivity 83,33 %  and Specificity 95,65% of  , PPV  90,91%and NPV 91,67%, Diagnostic Accuracy 91,43 % . Xpert MTB/RIF Sensitivity 75% and Specificity 95,65% , PPV  90 % and NPV 88 %, Diagnostic Accuracy 88,57 % with 95% CI (Confidence Interval ) . Characteristics female dominated 23/35 (65.7%) while Male numbered 12/35 (34.3%), age range distribution of TB lymphadenitis patients is highest in young adults 17 years to 25 years as many as 15/35 (42.9%) the second highest is the age group of 36 years to 45 years by 8/35 (22.9%), Clinicial presentation are mostly lymph node enlargement in cervical  37% patients other locations supraclavicular ,mamae. Clinical symptoms mostly lymphadenopathy 31,5% and other lymphadenopathy with fever. Microscopy method still have the good validity shoul be conjunction with the  molecular rapid tests and culture as gold standard in determining the diagnosis of TB lymphadenitis.
Risk Factors of Covid-19 Confirmed Died Patients in Dr. Kariadi Hospital: A Retrospective Study Elyana Sri Sulistyowati; Septi Sewi Muninggar; Verarica Silalahi
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.22609

Abstract

Covid-19 is a communicable disease causing global pandemic. Some factors inflict worse infection. This study aims to investigate risk factors of Covid-19 confirmed died patients at Dr. Kariadi Hospital Semarang. It is a retrospective study with a total sample of all Covid-19 confirmed patients involving died and healed patients from March to June 2020. Data was gathered from screening forms and analysed with Chi Square (confidence interval of 95%). This study found sixteen risk factors of Covid-19 confirmed died patients involving age (p= 0.000; OR= 8.803; 95% CI 3.982-19.462), entrepreneur (p= 0.041; OR= 14.894; 95% CI 1.12-198.65), farmer/trader (p= 0.029; OR= 25.625; 95% CI 1.40-469.25), contact history (p= 0.000; OR= 12.923; 95% CI 6.163-27.097), fever (p= 0.000; OR= 4.877; 95% CI 2.647-8.984), dyspnea (p=0.000; OR= 17.018; 95% CI 8.523-33.977), cough (p= 0.009; OR= 2.178; 95% CI 1.205-3.935), lethargic (p=0.010; OR= 2.282; 95% CI 1.205-4.323), cold (p= 0.002; OR= 0.180; 95% CI 0.054-0.600), diabetes (p=0.000; OR= 9.767; 95% CI 3.932-24.263), COPD (p= 0.001; OR= 6.360; 95% CI 2.164-18.690), hypertension (p= 0.043; OR= 2.436; 95% CI 1.008-5.887), cancer (p=0.001; OR= 9.647; 95% CI 2.413-38.579), heart disease (p= 0.000; OR= 12.226; 95% CI 2.4-62.294), neurological disorders (p=0.008; OR= 6.057; 95% CI 1.650-22.232), and immune disorders (p=0.031; OR= 1.625; 95% CI 1.186-113.899). Adequate handling is needed to prevent death. in patients with confirmed Covid-19 who have risk factors.
Diagnosis Based on Detection of CXCL10 in Urine as Biomarker for The Determining Diagnosis of Active Lung Tuberculosis Ni Made Mertaniasih; I Gede Yogi Prema Ananda; Soedarsono Soedarsono; Deby Kusumaningrum
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 1 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i1.22160

Abstract

Tuberculosis diagnosis is an important component in decreasing TB incidence and prevalence. Because of the difficulty to collect sputum in some cases, urine specimens are used as it is easier to garner. One of the biomarkers in urine that can be used to diagnose pulmonary TB is IP-10, which can be represented by the CXCL10 gene. The study aims to determine the accuracy of diagnosis based on detection of the CXCL10 gene in urine as a biomarker for the patients with suspected pulmonary TB in Dr. Soetomo Hospital in Surabaya from November 2019 until March 2020. Thus, this is an observative laboratory research with a cross-sectional study. CXCL10 gene was examined using PCR for 36 urine samples, and then, the data, together with the medical records of clinical manifestations of pulmonary TB, GeneXpert MTB /RIF, blood count, and thorax radiograph, were processed using IBM SPSS Statistics 26. The results of the GeneXpert MTB/RIF and thorax radiograph criteria show positive results of pulmonary TB, which were 44.4% and 69.4% respectively. CXCL10 gene was not found in all urine of healthy people (negative), while 2.8% (1/36 samples) positive CXCL10 gene was found in a patient with positive GeneXpert, also with negative clinical manifestations and urine culture. In this study, the accuracy of diagnosis based on detection of the CXCL10 gene in urine for diagnosis of active pulmonary TB was 2.8%. Future research is needed to improve the methods, among them are bigger size of urine samples and clearer medical history of patients. 

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